A research team discovered a direct link between higher presence of corticotropin-releasing stress hormone and increased degranulation mast cells (the main actor in immediate allergic reactions). Through their research using nasal polyp organ culture and mouse models, they also found also promising therapeutic pathways for stress-aggravated, MC-dependent mucosal inflammation, namely, nasal allergy.
Reference: Mika Yamanaka-Takaichi, Yukari Mizukami, Koji Sugawara, Kishiko Sunami, Yuichi Teranishi, Yukimi Kira, Ralf Paus, Daisuke Tsuruta. Stress and Nasal Allergy: Corticotropin-Releasing Hormone Stimulates Mast Cell Degranulation and Proliferation in Human Nasal Mucosa. International Journal of Molecular Sciences, 2021; 22 (5): 2773 DOI: 10.3390/ijms22052773Read the entire article